Publications

1. Akoumianaki T, Vaporidi K, Diamantaki E, Pène F, Beau R, Gresnigt MS, Gkountzinopulou M, Venichaki M, Drakos E, El-Benna J, Samonis G, Le KTT, Kumar V, Georgopoulos D, van de Veerdonk FL, Netea MG, Latge JP, Chamilos G.
Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
Cell Host Microbe. 2021 Jun 25;S1931-3128(21)00280-8. Online ahead of print. doi: 10.1016/j.chom.2021.06.002.

2. Hérivaux A, Willis JR, Mercier T, Lagrou K, Gonçalves SM, Gonçales RA, Maertens J, Carvalho A, Gabaldón T, Cunha C.
Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients
Thorax. 25 Jun 2021 doi: 10.1136/thoraxjnl-2020-216179.

3. Samuel M Gonçalves, Daniela Antunes, Luis Leite, Toine Mercier, Rob Ter Horst, Joana Vieira, Eduardo Espada, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, António Marques, Frank L van de Veerdonk, Leo A B Joosten, Katrien Lagrou, Johan Maertens, Mihai G Netea, João F Lacerda, António Campos Jr, Cristina Cunha, Agostinho Carvalho.
Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis
mBio 2021 May 28;e0036921 doi: 10.1128/mBio.00369-21. Online ahead of print.

4. Andrea Doni, Raffaella Parente, Ilaria Laface, Elena Magrini, Cristina Cunha, Federico Simone Colombo, João F Lacerda, António Campos Jr, Sarah N Mapelli, Francesca Petroni, Rémi Porte, Tilo Schorn, Antonio Inforzato, Toine Mercier, Katrien Lagrou, Johan Maertens, John D Lambris, Barbara Bottazzi, Cecilia Garlanda, Marina Botto, Agostinho Carvalho, Alberto Mantovani.
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus
Nat Commun 2021 Jun 18;12(1):3739. doi: 10.1038/s41467-021-24021-y.

5. d'Enfert C, Kaune AK, Alaban LR, Chakraborty S, Cole N, Delavy M, Kosmala D, Marsaux B, Fróis-Martins R, Morelli M, Rosati D, Valentine M, Xie Z, Emritloll Y, Warn PA, Bequet F, Bougnoux ME, Bornes S, Gresnigt MS, Hube B, Jacobsen ID, Legrand M, Leibundgut-Landmann S, Manichanh C, Munro CA, Netea MG, Queiroz K, Roget K, Thomas V, Thoral C, Van den Abbeele P, Walker AW, Brown AJP.
The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives
FEMS Microbiol Rev. 2021 May 5;45(3):fuaa060. doi: 10.1093/femsre/fuaa060.PMID: 33232448.

6. Sophie Austermeier, Marina Pekmezović, Pauline Porschitz, Sejeong Lee, Nessim Kichik, David Moyes, Jemima Ho, Natalia K Kotowicz, Julian R Naglik, Bernhard Hube, Mark S Gresnigt.
Albumin Neutralizes Hydrophobic Toxins and Modulates Candida albicans Pathogenicity
mBio 2021 Jun 22;e0053121. doi: 10.1128/mBio.00531-21. Online ahead of print.

7. Jose Manuel Sánchez-Maldonado, Ana Moñiz-Díez, Rob Ter Horst, Daniele Campa, Antonio José Cabrera-Serrano, Manuel Martínez-Bueno, María Del Pilar Garrido-Collado, Francisca Hernández-Mohedo, Laura Fernández-Puerta, Miguel Ángel López-Nevot, Cristina Cunha, Pedro Antonio González-Sierra, Jan Springer, Michaela Lackner, Laura Alcazar-Fuoli, Luana Fianchi, José María Aguado, Livio Pagano, Elisa López-Fernández, Esther Clavero, Leonardo Potenza, Mario Luppi, Lucia Moratalla, Carlos Solano, Antonio Sampedro, Manuel Cuenca-Estrella, Cornelia Lass-Flörl, Pcraga Study Group, Federico Canzian, Juergen Loeffler, Yang Li, Hermann Einsele, Mihai G Netea, Lourdes Vázquez, Agostinho Carvalho, Manuel Jurado, Juan Sainz.
Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium
J Fungi (Basel). 2020 Dec 23;7(1):4. doi: 10.3390/jof7010004.

8. Anaїs Hérivaux, Samuel M Gonçalves, Agostinho Carvalho, Cristina Cunha.
Microbiota-derived metabolites as diagnostic markers for respiratory fungal infections
J Pharm Biomed Anal 2020 Sep 10;189:113473. doi: 10.1016/j.jpba.2020.113473. Epub 2020 Jul 15.

9. Barbara Cellini, Teresa Zelante, Mirco Dindo, Marina M. Bellet, Giorgia Renga, Luigina Romani, Claudio Costantini.
Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of Host–Microbe Tryptophan Metabolism
Int. J. Mol. Sci. 2020, 21(16), 5823. doi: https://doi.org/10.3390/ijms21165823.

10. Gloria Castellano-González, Helen M McGuire, Fabio Luciani, Leighton E Clancy, Ziduo Li, Selmir Avdic, Brendan Hughes, Mandeep Singh, Barbara Fazekas de St Groth, Giorgia Renga, Marilena Pariano, Marina M Bellet, Luigina Romani, David J Gottlieb.
Rapidly expanded partially HLA DRB1–matched fungus-specific T cells mediate in vitro and in vivo antifungal activity
Blood advances 2020 Jul 28;4(14):3443-3456. doi: 10.1182/bloodadvances.2020001565.

11. Arianna Di Stadio, Claudio Costantini, Giorgia Renga, Marilena Pariano, Giampietro Ricci, Luigina Romani.
The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19
Life 2020 Dec 11;10(12):345. doi: 10.3390/life10120345.

12. Claudio Costantini, Frank L van de Veerdonk, Luigina Romani.
Covid-19-Associated Pulmonary Aspergillosis: The Other Side of the Coin
Vaccines 2020 Dec 1;8(4):713. doi: 10.3390/vaccines8040713.

13. Amir Arastehfar, Agostinho Carvalho, M. Hong Nguyen, Mohammad Taghi Hedayati, Mihai G. Netea, David S. Perlin, Martin Hoenigl.
COVID-19-Associated Candidiasis (CAC): An Underestimated Complication in the Absence of Immunological Predispositions?
J Fungi (Basel). 2020 Dec; 6(4): 211. doi: 10.3390/jof6040211.

14. Gonçales RA, Bastos HN, Duarte-Oliveira C, Antunes D, Sokhatska O, Jacob M, Rolo R, Campos CF, Sasaki SD, Donato A, Mapelli SN, Costa S, Moura CS, Delgado L, Morais A, Torrado E, van de Veerdonk FL, Weichhart T, Lambris JD, Silvestre R, Garlanda C, Mantovani A, Cunha C, Carvalho A.
Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis
American Journal of Respiratory and Critical Care Medicine 2022 Nov 1;206(9):1140-1152- doi: 10.1164/rccm.202112-2771OC.

15. Da Silva-Ferreira S, Duarte-Oliveira C, Antunes D, Barbosa-Matos C, Mendes-Frias A, Torrado E, Costa S, Silvestre R, Cunha C, Carvalho A.
Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation
Frontiers in Cellular and Infection Microbiology 2022;12:1005839. doi: 10.3389/fcimb.2022.1005839.

16. Matzaraki V, Beno A, Jaeger M, Gresnigt MS, Keur N, Boahen C, Cunha C, Gonçalves SM, Leite L, Lacerda JF, Campos A Jr, van de Veerdonk FL, Joosten L, Netea MG, Carvalho A, Kumar V.
Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis
Redox Biology 2022 Jul 4;55:102391. doi: 10.1016/j.redox.2022.102391.

17. Hoenigl M, Seidel D, Carvalho A, Rudramurthy SM, Arastehfar A, Gangneux JP, Nasir N, Bonifaz A, Araiza J, Klimko N, Serris A, Lagrou K, Meis JF, Cornely OA, Perfect JR, White PL, Chakrabarti A.
The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries
Lancet Microbe 2022 Jul;3(7):e543-e552. doi: 10.1016/S2666-5247(21)00237-8.

18. Gonçalves SM, Ferreira AV, Cunha C, Carvalho A.
Targeting immunometabolism in host-directed therapies to fungal disease
Clinical Experimental Immunology 2022 Jun 11;208(2):158-166. doi: 10.1093/cei/uxab014.

19. De Castro PA, Colabardini AC, Moraes M, Horta MAC, Knowles SL, Raja HA, Oberlies NH, Koyama Y, Ogawa M, Gomi K, Steenwyk JL, Rokas A, Gonçales RA, Duarte-Oliveira C, Carvalho A, Ries LNA, Goldman GH.
Regulation of gliotoxin biosynthesis and protection in Aspergillus species
PLoS Genetics 2022 Jan;18(1):e1009965. doi: 10.1371/journal.pgen.1009965.

20. Arastehfar A, Carvalho A, Houbraken J, Lombardi L, Garcia-Rubio R, Jenks JD, Rivero-Menendez O, Aljohani R, Jacobsen ID, Berman J, Osherov N, Hedayati MT, Ilkit M, Armstrong-James D, Gabaldón T, Meletiadis J, Kostrzewa M, Pan W, Lass-Flörl C, Perlin DS, Hoenigl M.
Aspergillus fumigatus and aspergillosis: From basics to clinics
Studies in Mycology. 2021 May 10;100:100115- doi: 10.1016/j.simyco.2021.100115.

21. Ries LNA, Alves de Castro P, Pereira Silva L, Valero C, Dos Reis TF, Saborano R, Duarte IF, Persinoti GF, Steenwyk JL, Rokas A, Almeida F, Costa JH, Fill T, Sze Wah Wong S, Aimanianda V, Rodrigues FJS, Gonçales RA, Duarte-Oliveira C, Carvalho A, Goldman GH.
Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity
mBio 2021 Aug 31;12(4):e0168221. doi: 10.1128/mBio.01682-21.

22. Gonçales RA, Ricci-Azevedo R, Vieira VCS, Fernandes FF, Thomaz SMO, Carvalho A, Vendruscolo PE, Cunha C, Roque-Barreira MC, Rodrigues F.
Paracoccin Overexpression in Paracoccidioides brasiliensis Enhances Fungal Virulence by Remodeling Chitin Properties of the Cell Wall
Journal of Infectious Diseases 2021 Jul 2;224(1):164-174. doi: 10.1093/infdis/jiaa707.

23. Hérivaux A, Willis JR, Mercier T, Lagrou K, Gonçalves SM, Gonçales RA, Maertens J, Carvalho A, Gabaldón T, Cunha C.
Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients
Thorax 2022 Mar;77(3):283-291. doi: 10.1136/thoraxjnl-2020-216179.

24. Simon Feys, Samuel M Gonçalves, Mona Khan, Sumin Choi, Bram Boeckx, Denis Chatelain, Cristina Cunha, Yves Debaveye, Greet Hermans, Marjan Hertoghs, Stephanie Humblet-Baron, Cato Jacobs, Katrien Lagrou, Lukas Marcelis, Julien Maizel, Philippe Meersseman, Rémy Nyga, Laura Seldeslachts, Marick Rodrigues Starick, Karin Thevissen, Christophe Vandenbriele, Lore Vanderbeke, Greetje Vande Velde, Niels Van Regenmortel, Arno Vanstapel, Sam Vanmassenhove, Alexander Wilmer, Frank L Van De Veerdonk, Gert De Hertogh, Peter Mombaerts, Diether Lambrechts, Agostinho Carvalho, Johan Van Weyenbergh, Joost Wauters.
Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study
The Lancet Respiratory Medicine. 2022, P1147-1159. doi: 10.1016/S2213-2600(22)00259-4.

25. Emilia Nunzi, Giorgia Renga, Melissa Palmieri, Giuseppe Pieraccini, Marilena Pariano, Claudia Stincardini, Fiorella D’Onofrio, Ilaria Santarelli, Marina Maria Bellet, Andrea Bartoli, Claudio Costantini, Luigina Romani.
A shifted composition of the lung microbiota conditions the antifungal response of immunodeficient mice
International Journal of Molecular Sciences 2021 Aug 6;22(16):8474. doi: 10.3390/ijms22168474.

26. Claudio Costantini, Emilia Nuinzi, Luigina Romani.
From the nose to the lungs: the intricate journey of airborne pathogens amid commensal bacteria
American Physiological Society Epub 2022 Aug 29. doi: 10.1152/ajpcell.00287.2022.

27. Claudio Costantini, Emilia Nunzi, Angelica Spolzino, Francesco Merli, Luca Facchini, Antonio Spadea, Lorella Melillo, Katia Codeluppi, Francesco Marchesi, Gessica Marchesini, Daniela Valente, Giulia Dragonetti, Gianpaolo Nadali, Lukas Englmaier, Katerina Coufalikova, Zdeněk Spáčil, Marina Maria Bellet, Marilena Pariano, Giorgia Renga, Claudia Stincardini, Fiorella D'Onofrio, Silvia Bozza, Livio Pagano, Franco Aversa, Luigina Romani.
A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants
American Society for Microbiology. 2022 Apr 21;90(4):e0004822. doi: 10.1128/iai.00048-22.